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KMID : 1134820140430060829
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 6 p.829 ~ p.835
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Neuroprotective Effects of Bread Containing Cirsium setidens or Aster scaber
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Kwon Ki-Han
Lim Hee-Kyung
Chung Mi-Ja
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Abstract
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This study investigated the neuroprotective effects of bread containing extract from Cirsium setidens (CS) or Aster scaber (AS) against H2O2-induced death of human brain neuroblastoma SK-N-SH cells. Treatment with bread containing extract from CS (CSB) or AS (ASB) reduced H2O2 cytotoxicity in SK-N-SH cells, the intracellular ROS level, and the phospho-p38 mitogen-activated protein kinase (MAPK) level. In the sensory evaluation, wild vegetable flavor scores of CSB were higher than those of ASB and bread containing 0% CS or AS (NB). In terms of appearance, color, flavor, softness, and overall acceptability, CSB and ASB showed higher scores than NB, but no differences were observed between CSB and ASB. These results indicate that CSB and ASB have potent health benefits in terms of neuroprotection against oxidative stress mediated through antioxidant activity and inhibition of p38 phosphorylation in brain neural cells. Thus, CS and AS could be considered as a health functional material.
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KEYWORD
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antioxidant activity, brain, neuroprotective effects, oxidative stress, SK-N-SH cells
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